Profile Number of Mice Takizoit after Treatment With Alkaloid Fraction of Alstonia scholaris Leaves

Abdul Hakim

Abstract


The prevalence of toxoplasmosis in Indonesia at 2006 was 43-88%. Drugs that have been the most widely used for the treatment of patients with toxoplasmosis include pyrimethamine and spiramicin. However, these drugs have been reported to cause side effects such as bone marrow suppression, penetrate the blood brain barrier, crossed the placenta and fetal blood. Therefore necessary to find alternative drugs for toxoplasmosis effective and safe. This research studied the effect of alkaloid fraction of leaves of plants Alstonia scholaris to the number takizoit profiles in intraperitoneal fluid of mice infected with Toxoplasma gondii. This research used the experimental animals were grouped as the control group and the treatment group. In the treatment group, each group was given treatment with fraction extract alkaloids from leaves of plants Pulai. The results showed the number takizoit mice infected with Toxoplasma gondii parasites without therapy is 957.5 x 103 whereas the alkaloid fraction of the ethanol extract of leaves is 737.5 x 103.

 

Keywords: Leaves of Pulai (Alstonia scholaris), Toxoplasma gondii, toxoplasmosis.


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References


Iskandar T., Didik T.S., Eka F. D. 2006. Gambaran Splenosit, Limpa dan Kekebalan pada Mencit Galur Balb/c Yang Diberi Alantoin dan Dinfeksi Toxoplasma gondii. Bogor. Seminar Nasional Teknologi Peternakan dan Veteriner.

Susanto, L., Supali, T. dan Gandahusada. S. 2002, Kesehatan, Vol. 6, No. 2: 64-70.

Subekti, D. T., dan Arrasyid, N, K. 2006, Wartazoa. Vol.6. No. 3: 128-145.

JP Dubey, M. Louis Weiss, Toxoplasmosis: A History of Clinical Observations. Departments of Medicine (Division of Infectious Diseases) and Pathology (Division of Parasitology), AlbertEinstein College of Medicine, Animal Parasitic Diseases Laboratory, Animal and Natural Resources Institute Agricultural ResearchService, United States Department of Agriculture, 2009.

Wibisono, D.S .2005. Ragam Medikamentosa Terapi Toksoplasmosis pada Kehamilan.SMF Kebidanan dan Penyakit Kandungan RSUP Fatmawati, Jakarta. Subbagian Immuno Endokrin Reproduksi Kebidanan FKUI-RSCM Jakarta.

Kumolosasi E.., S. Elin Yulinah, W Komar Ruslan, US Andrenaus, Sundani Nurono, 1999, Making preparations Phytopharmaca Against Diseases Toxoplasmosis, caused by Toxoplasma gondii is Effective and Safe, Competitive Grant Research Report VII, ITB, Bandung.

Subekti, D. T., dan Arrasyid, N, K. 2006, Wartazoa. Vol.6. No. 3: 128-145.




DOI: https://doi.org/10.18860/jip.v1i1.3455

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