Catechins Green Tea Clones GMB4 Inhibit Inflammation Process of Atherosclerosis Through Decreasing TNF-Α Levels

Erna Susanti, Febiyanti Suratno

Abstract


Catechins Green tea clones GMB4 are potential natural subtances to inhibit  inflammation process in atherosclerosis. The purpose of this research to determine activity of  Catechins Green tea clones GMB4 to decrease TNF-α levels, as well as to determine optimal dose of Catechins. This research was conducted at the Laboratory of Physiology of the University of Brawijaya. The method used in this research is completely randomized design with five treatments: (1) Mice with standard feed (2) mice with high-fat diet (3) mice with high-fat diet + catechins 3mg / day (4) mice with a diet high fat + catechin 6mg / day (5) mice with high-fat diet + catechin 24mg / day. The treatment was done for 60 days and measured levels of TNF-α at the end of the research. The results showed that Catechins green tea clones GMB4 can inhibit the inflammatory process in atherosclerosis through decreasing levels of TNF-α at doses of 3mg / day. The conclusion of this research is catechins at a dose of 3 mg / day can inhibit inflammation in atherosclerosis significantly.

 

Keywords : GMB 4 green tea clones, Catechins, inflammation, TNF-α

Full Text:

PDF

References


World Health Organization. 2003. Deaths from coronary heart disease, Available from URL :http://www.who.int/cardiovascular_diseases/en/cvd_atlas_14_deathHD.pdf

Yang Z, Ming XF . 2006. Recent Advances in Understanding Endothelial Dysfunction in Atherosclerosis, Clinical Medicine & Research Review, 53-65.

DeFronzo, R.A. 2010. Insulin Resistance, Lipotoxicity, Type 2 Diabetes and Atherosclerosis : the Missing Link, Diabetologia Reviews

Muniyappa R, Montagnani M, Kon Koh K, Guon, MJ. 2007. Cardiovascular Actions of Insulin, Endocrine Reviews.

Ratnawati, R.; Ciptati; Satuman .2009. Isolation EGCG from green tea GMB4 Clones, West Java. Reports of Incentive Program Basic Research. RISTEK, Ministry of Research and Technology

Aulanni'am. 2003. Principles and techniques of Biomolecular analysis. 78-81

Rantam FA. 2003. Methods Imunology. Airlangga University Press.105-122

Ali M, Muliartha IK. 2004. Optimization of High-Fat Diet in Rats Models Atherogenik, UB Medical Journal: 3 (2): 15-21

Choo JJ. 2003. Green tea reduces body fat accretion caused by high fat diet in rats trough beta adrenoceptor activation of thermogenesis in brown adipose tissue. J. Nutr. Biochem 14 : 671-676.

Stangl V, Dreger H, Stangl K, ,Moleculer Targets of Tea Polyphenols in the Cardiovascular System , Cardiovascular Research, Oxvord Journal vol 73 issue 2, p. 348-358.

Velayutam P. Babu and Liu. 2008. Green Tea Catechins and Cardiovascular Health ; An Update, Current Medicinal Chemistry, vol 15. No. 18, pp. 1840-1850




DOI: http://dx.doi.org/10.18860/jip.v1i1.3458

Refbacks

  • There are currently no refbacks.