EVOLUTION AND EFFECTIVENESS OF COLORMETRIC APPROACH FOR INVESTIGATION OF CEFTRIAXONE MEDICINE AS IN PURE FORM AND IN FORMULATION VIALS

Mohauman Mohammad Majeed Al-Rufaie

Abstract


A third-generation cephalosporin antibiotic was aceftriaxone medicine. Similar another (3rd generation cephalosporins), it has wide broad spectrum effectiveness versus gram positive as well as gram negative bacteria. Diverse approachs for analyses of the studied medicine are obtainable but are costly additionally time consumption. Therefor we have sophisticated developed novel, easy, simple as well as accurate colormetric approach for investigation of ceftriaxone medicine as pure form as well as in formulation vials by depending on  a specific color-generated reaction. This reaction involves the Schiff 's base formation reaction between ceftriaxone drug  with alcoholic 4- di ethyl amino benzaldehyde  (DEAB) reagent to produce a new ligand that reacts with cobalt (II) ion with heating to (50°C) in acidic media to form green colored complex exhibiting λmax at 496 nm. The medicine conformed with the Beer’s law with the linearity was observed between (2 –52) μg/ml additionally that  correlation coefficient was 0.9992 .The analyses outcomes were supported with LOD, LOQ, accuracy, recovery studies, ruggedness as well as precision. The approach was establish to be robust as well as economical.


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References


Indian Pharmacopoeia 1996 (Addendum 2002). (Govt. of India, Ministry of Health and Family Welfare, Controller of Publications, Delhi,2002,77.

N. J. Montvale, Physician’s Desk Reference, (Medical Economics Company Inc Montvale,2003,56.

A. Mazza: Ceftriaxone as short-term antibiotic prophylaxis in orthopedic surgery: a cost-benefit analysis involving 808 patients , J Chemother.,2000, 3, 29-33.

The British Pharmacopoeia, Her Majesty’s Stationary Office, London,2009, 1169,8255.

S. Eric, D. Agbaba, K. Karljikovic-Rajic, D. Zivanov Stakic and S. Vladimirov: HPTLC determination of ceftriaxone, cefixime and cefotaxime in dosage forms,J. Pharm. Biomed. Anal.,1998,18 (4-5), 893- 899.

S. A. Nabi , E. Laiq and A. Islam: Selective Separation and Determination of Cephalosporins by TLC on Stannic Oxide Layers , Acta Chromatogr.2000,14, 92-101.

T. Tomasz: Two-dimensional thin-layer chromatography of eight cephalosporins on silica gel layers ,JPC-Modern TLC.,2004,17 (1) ,46-50.

B. Morelli: Simultaneous determination of ceftriaxone and streptomycin in mixture by ‘ratio-spectra’ 2nd derivative and ‘zero-crossing’3rd derivative spectrophotometry, Talanta.,1994,41(5), 673-683.

S. Alaa, Amin and H.R. Gamal: Spectrophotometric determination of certain cephalosporins in pure form and in pharmaceutical formulations, Spectrochim. Acta Part A: Molec. Biomolec. Spect.,2004,60 (12), 2831- 2835.

Y. N. Ni and C.X. Ge:,Simultaneous spectrophotometric determination of certain beta-lactam antibiotics in rabbit serum using multivariate calibration methods, Guang Pu Xue Yu Guang Pu Fen Xi.,2007,27(2), 355-362.

D. G. Sankar, B. A. Kumar, N. Sujatha and P. V. M. Latha: Development And Validation of UV–Spectrophotometric Methods For Estimation of Ceftriaxone In Bulk And Tablet Dosage Form, Acta Cien. Ind. Chem.,2006, 32 (2) ,147-153.

B. Franciszek and S. Barbara: Spectrophotometric Determination of Cephalosporins with Leuco Crystal Violet, Chem. Anal. (Warsaw).,2003,48,145-149.

K. R. Patel, V. D. Patel, K. P. Patel and V. G. Patel: Development and Validation of Spectrophotometric Method for Determination of Ceftriaxone Sodium in Pharmaceutical Dosage Forms, Der Pharma Chemica,2010,2(5),255–259.

K. S. Lakshmi, K. Ilango, M. N. Nithya, S. Balaji, V.W.D. Kibe and A.V.S. Kumar:A new spectrophotometric method has been developed for the determination of the potent antibiotic ceftriaxone sodium, A. J. Chem.,2007,19 (4), 2517- 2522.

S. A. Patel, N. M. Patel and M. M. Patel: Spectrophotometric estimation of cefotaxime and ceftriaxone in pharmaceutical dosage forms, I. J. Pharm. Scien.,2006,68 (1),101-103.

R. E. Salwa, A. S. Gamal, A. M. Fardous and H. R. Azza: Analysis of cephalosporin antibiotics, J. Pharm. Biomed. Anal.,2007, 45 (1),1-19.

L.I. Bebawy, K. El-Kelani and L. A. Fattah: Fluorimetric determination of some antibiotics in raw material and dosage forms through ternary complex formation with terbium (Tb3+), J. Pharm. Biomed. Anal.,2003,32(6),1219-1225.

H.Yao, Y. Tang, Y. Li, and Y. Sun: Flow injection chemiluminescence determination of cephalosporin antibiotics by their enhancing effects on luminal-potassium periodate system, Anal. Lett.,2003,36 (14),2975–2983.

M.E. Abdel-Hamid: FSQ spectrophotometric and HPLC analysis of some cephalosporins in the presence of their alkali induced degradation products,Il Farmaco,1998;53 (2),132–138.

L. D. Antonio, M. Antonio and O. Regina:VO2+ and Cu2+ Interactions with Ceftriaxone and Ceftizoxime. HPLC Kinetic Studies, J. Braz. Chem. Soci.,2002, 13 (1),95-100.

V.V. Khasanov, E. G. Sokolovich and K. A. Dychko: Determination of ceftriaxone in blood and tissues using ion-exchange chromatography, Pharm.Chem.,2006,40(2)109-111.

D. J. Nickolai ,C. J. Lammel , B. A. Byford , J. H. Morris , E. B. Kaplan ,W. K. Hadley and G F Brooks: Effects of storage temperature and pH on the stability of eleven beta-lactam antibiotics in MIC trays, J. Clin. Microbiol.,1985,21(3),366-370.

L. N. C. Rodrigues, M. B. V. Zanoni, and A. G. Fogg: Indirect polarographic and cathodic-stripping voltammetric determination of cefaclor as an alkaline degradation product, J. Pharm. Biomed. Anal.,1999, 21 (3), 497–505.

V. S. Ferreira, M.V.B. Zanoni, and A.G. Fogg: Cathodic stripping voltammetric determination of ceftazidime with reactive accumulation at a poly-L-lysine modified hanging mercury drop electrode, Anal. Chim. Acta,1999, 384 (2), 159–166.

K. Kelani, L. I. Bebawy, and L. Abdel-Fattah: Stability-indicating spectrophotometric and densitometric methods for determination of some cephalosporins, J.AOAC Int., 1998, 81 (2), 386–393.

M. M. Al-Rufaie, A.N.Al-Sharefy, K.H.Kathem: New spectrophotometric method for the determination chlorpromazine hydrochloride in pharmaceutical preparations by using oxidative coupling reaction. Inter. J. of Uni. Pharmacy and Bio Sciences, 2013,2(4), 184-189.

F. M. A. Rind, M. G. H. Laghari, A. H. Memon, U.R. Mughal, F. Almani, N. Memon, M. Y. Khuhawar, and M. L. Maheshwari: Spectrophotometric Determination of Ceftriaxone Using 4-Dimethylaminobenzaldehyde, Pak.J.Anal. Environ. Chem.,2008,9(2),42–48.

M. M. Al-Rufaie: Modern kinetic spectrophotometric procedure for estimation of furosemide drug as bulk form and in pharmaceuticals preparations, Curr. Issues Pharm. Med. Sci.2016,29(4),184–189.

B. Hiremath, B.H. Mathada, and M. unjayaswam: Development and validation of spectrophotometric methods for determination of ceftazidime in pharmaceutical dosage forms, Acta Pharm.,2008,58, 275–285.

A.A.Jawad and K.H.Kathem: spectrophotometric determination of metoclopramide hydrochloride in bulk and pharmaceutical preparations by diazotization-coupling reaction, Inter.J.of Pharmacy and Pharmaceutical Sciences,2013.5(3),294-298.

M. I. H. Helaleh, E. S.M. Abu-Namch, and R. M. A. Q. Jamhour: Direct titration and indirect spectrophotometric determination of selected cephalosporins, acta poloniae pharmaceutica,1998,55(2),93–97.

A. A. Ramadan, H. Mandil, and M. Dahhan: UV-VIS Spectrophotometric study for determination of cefixime in pure form and in pharmaceuticals through complexation with Cu(II) using acetate–NaOH buffer in water: methanol, International J. of Pharmacy and Phar. Sci.,2013,5(1),428–433.

D. Harvey, (2000), Modern Analytical Chemistry, Mc Graw-Hill Higher Edu. USA,2000,116




DOI: http://dx.doi.org/10.18860/jip.v3i2.6099

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