Pengaruh Variasi Konsentrasi Propilen Glikol Sebagai Enhancer Terhadap Sediaan Transdermal Patch Ibuprofen In Vitro

Misnamayanti Misnamayanti, Hajar Sugihantoro, Begum Fauziyah

Abstract


Ibuprofen is an anti-inflammatory class of non-steroidal propionic acid used in the treatment of osteoarthritis, analgesics, and antipyretics. Ibuprofen made in a transdermal patch to avoid side effects of irritation to the stomach, first pass effect on application oral. This aims of the research to determine the physical characteristics of the patch, the effect of propylene glycol concentration (150 mg, 200 mg, 250 mg) on the thickness patch, pH, and the rate of penetration as increase in penetration of the ibuprofen transdermal patch. Patch preparations were made in 3 draft formulas with varying concentrations of propylene glycol 150 mg, 200 mg, and 250 mg. The method used for penetration testing is Franz diffusion cells. The results of physical characteristics are clear, odorless, dry, not cracked,> 300 folds, thickness ranges from 0.142 to 0.184. The concentration of propylene glycol effects (p-value> 0.05) the penetration and no effect (p-value> 0.05) the pH test. Increasing the concentration of propylene glycol causes an increase medicine that penetrate the skin.

Keywords: Ibuprofen, transdermal patch, propylene glycol


References


Katzung, B.G. 2003. Drugs Used in Disorders of Coagulation, in: Basic & Clinical Pharmacology. Mcgraw-Hill. 9th Ed.P.775-776.

BNF. 2009. Bnf Children: The Essential Resource For Clinical Use Of Medicines In Children, Bmj Group, Germany.

Waranugraha, Y., Putra, B.P. dan Suryana, B.P. Hubungan Pola Penggunaan OAINS dengan Gejala Klinis Gastropati pada Pasien Reumatik Relationship of NSAID Utilization Pattern With Gastropathy Symptoms in Rheumatic Patient. Jurnal Kedokteran Brawijaya, 2010; 26 (2).

Madhulatha, A. dan Naga, T.R. Formulation And Evaluation of Ibuprofen Transdermal Patches. International Journal Of Research In Pharmaceutical And Biomedical Sciences, 2013; 4 (1).

Gungor, S., Erdal, M. E. dan Ozsoy, Y. 2012. Plasticizer in Transdermal Drug Delivery System. Recent Advances in Plasticizer. Beyazit-Istanbul: Turki

Williams, A.C. dan Barry, B.W. 2004. Penetration Enhancers. Advanced Drug Delivery Reviews. 5 (6): 603-618.

Rowe, R. C., Sheskey, P,.J. dan Quinn, M,E. 2009. Handbook of Pharmaceutical Excipients Sixth Edition. Pharmaceutical Press: London.

Mehsen, M.B. Effect Of Propylene Glycol, Poly Ethylene Glycol 400 And Ph On The Release And Diffusion Of Ibuprofen From Different Topical Bases. AJPS, 2011; 9 No.1.

Zakinah, H.R. 2016. Pengaruh Propilen Glikol dalam Patch Dispersi Padat Ketoprofen Terhadap Karakteristik Fisika Kimia da Laju Penetrasinya. [Skripsi]. Jember. Fakultas Farmasi Universitas Jember.

Gaikwad, A.K. Transdermal Drug Delivery System: Formulation Aspect and Evaluation. Comprehensive Journal of Pharmaceutical Science, 2013; 1 (1).

Wulandari, S.A.R. 2017. Formulasi dan Uji Aktivitas Antibakteri Stapylococcus Epidemidis Sediaan Mikroemulsi Ekstrak Daun Kersen (Muntingia Calabura Linn.) dengan Fase Minyak Isopropil Mirystate [Skripsi]. Malang: Fakultas Kedokteran Dan Ilmu Kesehatan Universitas UIN Malang.




DOI: https://doi.org/10.18860/jip.v4i2.8029

Refbacks

  • There are currently no refbacks.


© 2019 Journal of Islamic Pharmacy - All rights reserved