ASSEMBLY PROPERTIES OF GOLD NANODISCS MODIFIED WITH ALKYNE AND AZIDE LIGANDS

Melda Taspika

Abstract


Plasmonic nanoparticle assemblies have attracted considerable interest for applications in biosensing, optical devices, and biomedicine. Understanding the driving forces governing nanoparticle assembly is essential for controlling their structural and functional properties. Ligands play a critical role in regulating the assembly behavior of gold nanoparticles (AuNPs). In this study, gold nanodiscs (AuNDs) were functionalized with alkanethiol ligands via a ligand-exchange reaction, as indicated by changes in their zeta potentials before and after functionalization. The assembly behavior of AuNDs was strongly dependent on the ligand composition at their surfaces. AuNDs functionalized with thermoresponsive (C1) and carboxyl-functionalized (COOH) ligands exhibited reversible assembly and disassembly upon heating and cooling, respectively, as monitored by extinction spectroscopy. The incorporation of alkyne (Alk) or azide (N₃) ligands altered the assembly and disassembly temperatures, potentially owing to differences in ligand hydrophobicity. Because alkyne and azide groups can undergo copper(I)-catalyzed azide–alkyne cycloaddition (CuAAC), this functionalization strategy may provide a basis for developing covalently linked AuND assemblies with enhanced structural stability.

Keywords


Gold Nanodiscs; Assembly; Plasmonic Nanoparticle; Alkyne; Azide

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References


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DOI: https://doi.org/10.18860/neu.v19i1.43349

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