POTENSI ANTIMALARIA EKTRAK DIKLOROMETAN DAUN BUNGA MATAHARI (Helianthus annuus L.) SECARA IN VIVO PADA HEWAN COBA

Abstract

Antimalaria experiment on this research aimed to know the activity of extract sunflower leaf to the growth of parasit Plasmodium berghei   in mice balb/c. Mice is being infected by interaperitonial with 106 Plasmodium berghei and divided into 5 groups of treatment, they are (1) positive control, (2) artemisin control 0,004 mg/g BB, , (3) extract sunflower of dose 1 (0,05 mg/g BB), (4)

extract sunflower of dose 2 (0,5 mg/g BB) and extract sunflower of dose 3 (5 mg/g BB). Those experiment of antimalaria activity used Peter method. The therapy is done when degree of parasitemia after infected reach 5-15% that was counted as day -0 and it is given during 5 days. Monitoring the degree of parasitemia is done in day -0, day -1, day -2, day -3, and day -5. The result shows that all dose of extract diklorometan sunflower can kill parasit plasmodium berghei and degree of parasitemia reached 0% in day -3 and day -4 after therapy. The statistic analysis shows that the first, second, and third doses on the positive control group have siginificant differences with p < 0.05. on the artemism group, first, second, and third doses doesn’t show significant differences with p > 0.05. This shows that extract diklorometan having high potential as antimalaria and the effect is the same with artemism.