Hubungan Asupan Vitamin D Dan Selenium Dengan Indeks Bakteriologi Penderita Kusta Tipe MB (Multibacillary) : Systematic Literature Review

Fildzah Karunia Putri, Eka Zulfiana Yusyifak, Rizki Nurmalya Kardina

Abstract


Background : As one of the infectious diseases that have a high prevalence until now, leprosy is a chronic transmission disease caused by infection with Mycobacterium Leprae. Apart from the standard MDT (Multidrug Therapy), nutritional support is a crucial component to restrict further infection severity. Vitamin D and selenium play essential roles as the primary defence against susceptibility. Methods : The systematic literature review was conducted using three international databases : PubMed, ResearchGate, and DOAJ, which were published between 2010 – 2020 using English or Indonesian. A total of 8 articles (2 articles identifying the correlation of selenium with leprosy, and 6 articles identifying the correlation of vitamin D with leprosy) using cross- sectional analytic and case-control analytic studies were included in this review. Results : The average serum levels of vitamin D and selenium in leprosy patients were lower than in healthy controls. This case was also found in Multibacillary leprosy patients compared to Paucibacillary leprosy patients. This serum levels can affect the bacteriological index, which is the higher the serum levels, the lower the bacteriological index. Disscusion : Serum vitamin D and selenium levels are affected by vitamin D and selenium intake, which can lead to a reduction in bacteriological index across all multibacillary leprosy patients. There is a negative correlation between vitamin D, selenium, and bacteriological index in patients with MB (Multibacillary) leprosy.

Keywords:Leprosy, Vitamin D, Selenium, Bacteriological Index

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References


Satyareni, D. H. Sistem Pakar Diagnosis Penyakit Infeksi Tropis Dengan Menggunakan Forward Dan Backward Chaining. Teknologi. 2012. vol. 1, no. 2, pp. 61–67. doi: 10.26594/teknologi.v1i2.50.

Kemenkes RI. Hapuskan Stigma dan Diskriminasi terhadap Kusta. InfoDatin Pusat Data dan Informasi Kementrian Kesehatan RI. 2018. pp. 1–11.

Paschoal. D. Update on Genetics of Leprosy. J. Anc. Dis. Prev. Remedies. 2014. vol. 02, no. 01, pp. 1–6. doi: 10.4172/2329-8731.1000109.

Kumar, B., Uprety, S., and Dogra, S. Clinical diagnosis of leprosy. Int. Textb. 2018. Lepr. no. 1, pp. 1–24.

OMS. Global leprosy update 2018: moving towards a leprosy free world, Wkly. Epidemiol. 2019. Rec., vol. 35/36, no. 94, pp. 389–412. [Online]. Available: https://apps.who.int/iris/bitstream/handl e/10665/326775/WER9435-36-en-fr.pdf.

Kemenkes RI. Profil Kesehatan Indonesia 2018 [Indonesia Health Profile 2018]. 2019.

Vázquez, C. M. P, et al. Micronutrientes que influyen en la respuesta immune en la lepra. Nutr. Hosp. 2014. vol. 29, no. 1, pp. 26–36. doi: 10.3305/nh.2014.29.1.6988.

Sassi, F., Tamone, C., and D’amelio, P. Vitamin D: Nutrient, hormone, and immunomodulator, Nutrients. 2018. vol. 10, no. 11, pp. 1–14. doi: 10.3390/nu10111656.

Rusyati, L. M., Adiguna, M. S., Wiraguna, A. A. G. P., Puspawati, N. M. D., and Sudarsa, P. Correlation of serum Vitamin D receptor level with bacterial index in multibacillary leprosy patients at Sanglah General Hospital, Bali- Indonesia. Biomed. Pharmacol. J. 2019. vol. 12, no. 1, pp. 469–472. doi: 10.13005/bpj/1662.

Steinbrenner, H., Al-Quraishy, S., Dkhil, M. A., Wunderlich, F., and Sies, H., Dietary selenium in adjuvant therapy of viral and bacterial infections. Adv. Nutr. 2015. vol. 6, no. 1, pp. 73–82. doi: 10.3945/an.114.007575.

Partogi, D., Dalimunthe, D. A., and Hazlianda, C. P. A study of selenium in leprosy. Open Access Maced. J. Med. Sci. 2018. vol. 6, no. 3, pp. 485–487. doi: 10.3889/oamjms.2018.136.

Pepineli, A. C. et al. Vitamin D Receptor Gene Polymorphisms Are Associated With Leprosy in Southern Brazil. Front. Immunol. 2019. vol. 10, no. October, pp. 1–6. doi: 10.3389/fimmu.2019.02157.

Oktaria, S., Hurif, N. S., Naim, W., Thio, H. B., Nijsten, T. E. C. and Richardus, J. H. Dietary diversity and poverty as risk factors for leprosy in Indonesia: A case-control study. PLoS Negl. Trop. Dis. 2018. vol. 12, no. 3, pp. 1–15. doi: 10.1371/journal.pntd.0006317.

Garg V. et al. Vitamin a, c, d, e and b12 levels in leprosy: A case control study. Indian J. Lepr. 2020. vol. 92, no. 2, pp. 81–88. doi: 10.1016/j.jns.2019.10.1264.

Rusyati, L. M. M., Karmila, I. G. A. A. D., and Sudarsa, P. Increased risk of multibacillary leprosy among patient with low plasma vitamin D level. J. Glob. Pharma Technol. 2018.vol. 10, no. 5, pp. 29–35.

Singh I. et al. VDR polymorphism, gene expression and vitamin D levels in leprosy patients from North Indian population. PLoS Negl. Trop. Dis. 2018. vol. 12, no. 11, pp. 1–14. doi: 10.1371/journal.pntd.0006823.

Funderburk, L. L., Peterson, M., Shah, N., Morgan, M., and Grandjean, P. Serum vitamin D and body composition in adults undergoing fitness assessments: A correlation study. PLoS One. 2018. vol. 13, no. 6, pp. 1–10. doi: 10.1371/journal.pone.0197903.

Guillin, O. M., Vindry, C., Ohlmann, T., and Chavatte, L. Selenium, selenoproteins and viral infection. 2019. vol. 11, no. 9.

National Institutes of Health. Recommended Intakes. 2021. pp. 1 –35.

Grossi de Oliveira A. L. et al. Hypovitaminosis D and reduced cathelicidin are strongly correlated during the multidrug therapy against leprosy. Microb. Pathog. 2020. vol. 147, p.104373.doi:10.1016/j.micpath.2020.104373.




DOI: https://doi.org/10.18860/jim.v5i2.12974

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