Systematic Review : Kajian Fitokimia Dan Potensi Farmakologi Jeruk Pamelo (Citrus Maxima)

Roihatul Mutiah, M.Kes, Kesimira Qonita, Fitrati Hasanah Luthfi

Abstract


Background: The Citrus maxima plant is native to the Malay islands and East India. This plant grows widely in the tropics and has been widely used as medicine. Objectif: The purpose of this study was to study Citrus maxima from the aspect of phytochemical and pharmacological activity. Methods: The method used in this research is PRISMA systematic review. Sources of data obtained from electronic databases PubMed, Science Direct, and Google Scholar. Results: The results of a systematic review showed that the Citrus maxima plant contains naringin, hesperidin, hesperetin, rutin, nobiletin, tangeretin, vitamin C, limonene, lycopene, bergapten, umbelliferone and auraptene compounds. . Conclusion: These compounds have pharmacological activities as antioxidants, anticancer, antibacterial, anti-inflammatory, and antidiabetic

Full Text:

PDF

References


Ali, M. Y. et al. (2019) ‘Antioxidant potential, subacute toxicity, and beneficiary effects of methanolic extract of pomelo (Citrus grandis L. Osbeck) in long evan rats’, Journal of Toxicology, 2019. doi: 10.1155/2019/2529569. Arafa, E.-S. (2012) ‘Tangeretin Sensitizes Cisplatin-resistant Human Ovarian Cancer Cells through Down-regulation of PI3K/Akt Signaling Pathway’, Bone, 23(1), pp. 1–7. doi: 10.1158/0008-5472.CAN-09-1543.Tangeretin. Camargo, C. A. et al. (2012) ‘Naringin inhibits tumor growth and reduces interleukin-6 and tumor necrosis factor α levels in rats with Walker 256 carcinosarcoma’, Anticancer Research, 32(1), pp. 129–133. Chiang, C. C. et al. (2010) ‘A novel dimeric coumarin analog and antimycobacterial constituents from Fatoua pilosa’, Chemistry and Biodiversity, 7(7), pp. 1728–1736. doi: 10.1002/cbdv.200900326. Choi, S. Y. et al. (2007) ‘Correlation between flavonoid content and the NO production inhibitory activity of peel extracts from various citrus fruits’, Biological and Pharmaceutical Bulletin, 30(4), pp. 772–778. doi: 10.1248/bpb.30.772. Hasanah, U. (2018) ‘Penentuan Kadar Vitamin C Pada Mangga Kweni Dengan Menggunakan Metode Iodometri’, Jurnal Keluarga Sehat Sejahtera, 16(31), pp. 90–95. doi: 10.24114/jkss.v16i31.10176. Van Hung, P. et al. (2020) ‘Chemical Composition and Biological Activities of Extracts from Pomelo Peel By-Products under Enzyme and Ultrasound-Assisted Extractions’, Journal of Chemistry, 2020. doi: 10.1155/2020/1043251. Hwang, S. L. and Yen, G. C. (2008) ‘Neuroprotective effects of the citrus flavanones against H 2O 2-induced cytotoxicity in PC12 cells’, Journal of Agricultural and Food Chemistry, 56(3), pp. 859–864. doi: 10.1021/jf072826r. Kandaswami, C. et al. (1991) ‘Antitproliferative effects of citrus flavonoids on a human squamous cell carcinoma in vitro’, Cancer Letters, 56(2), pp. 147–152. doi: 10.1016/0304-3835(91)90089-Z. Kharjul, et al (2012) ‘PHARMACOGNOSTIC INVESTIGATION ON LEAVES OF CITRUS MAXIMA (BURM.) MERR. (RUTACEAE)’, 3(12), pp. 4913–4918. Li, G. et al. (2021) ‘Characterization of oxygenated heterocyclic compounds and in vitro antioxidant activity of pomelo essential oil’, Drug Design, Development and Therapy, 15, pp. 937–947. doi: 10.2147/DDDT.S299678. Manner, H. I. et al. (2020) ‘Species Profiles for Pacific Island Agroforestry Citrus ( citrus ) and Fortunella ( kumquat )’, (January 2006). Maritha, V. et al. (2021) ‘Aktifitas Sitotoksik Ekstrak Buah Jeruk Pamelo (Citrus Maxima) Terhadap Sel Kanker Servik’, 10(2), pp. 27–32. Patricia, A. D. and Mahatmanti, F. W. (2019) ‘Uji Daya Antibakteri Gel Hand Sanitizer Minyak Atsiri Seledri (Apium graveolens )’, Indonesian Journal of Chemical Science, 8(1), pp. 28–33. Pichaiyongvongdee, S. and Haruenkit, R. (2009) ‘Comparative studies of limonin and naringin distribution in different parts of pummelo [Citrus grandis (L.) Osbeck] cultivars grown in Thailand’, Kasetsart Journal - Natural Science, 43(1), pp. 28–36. Sowmya N (2019) ‘Exploring the total flavonoid content of peels of Citrus auriantum, Citrus maxima and Citrus sinensis using different solvents and HPLC-analysis of flavonones-Naringin and Naringenin in peels of Citrus maxima’, ~ 12 ~ The Pharma Innovation Journal, 8(4), pp. 12–17. Available at: www.thepharmajournal.com. Sri Wahdaningsih, Erna Prawita Setyowati, S. W. (2011) ‘AKTIVITAS PENANGKAP RADIKAL BEBAS DARI BATANG PAKIS (Alsophila glauca J. Sm)’, Majalah Obat Tradisional, 16(3), 16(3), pp. 156 – 160. Sujana, D., Wardani, D. and Nurul, N. (2020) ‘REVIEW ARTIKEL : POTENSI LIKOPEN DARI BUAH TOMAT (Solanum lycopersicum L) SEBAGAI ANTIAGING TOPIKAL’, Jurnal Insan Farmasi Indonesia, 3(1), pp. 56–65. doi: 10.36387/jifi.v3i1.479. Sun, Y. S. et al. (2017) ‘Risk factors and preventions of breast cancer’, International Journal of Biological Sciences, 13(11), pp. 1387–1397. doi: 10.7150/ijbs.21635. Tahir, M., Kusuma, A. T. and Ekawati (2018) ‘Analysis of Lycopene and Vitamin C Levels of Pamelo (Citrus maxima(Burm) Merr) Red and White Meat Varieties from South Sulawesi’, Journal of Current Pharmaceutical Science, 2(1), pp. 125–130. Available at: https://www.journal.umbjm.ac.id/index.php/jcps/article/view/172/114. Tzeng, Y. M. et al. (2011) ‘Insulin-mimetic action of rhoifolin and cosmosiin isolated from citrus grandis (L.) osbeck leaves: Enhanced adiponectin secretion and insulin receptor phosphorylation in 3T3-L1 cells’, Evidence-based Complementary and Alternative Medicine, 2011. doi: 10.1093/ecam/nep204. Venugopala, K. N., Rashmi, V. and Odhav, B. (2013) ‘Review on natural coumarin lead compounds for their pharmacological activity’, BioMed Research International, 2013(Table 1). doi: 10.1155/2013/963248. Werdhasari, A. (2014) ‘Peran Antioksidan Bagi Kesehatan’, Jurnal Biomedik Medisiana Indonesia, 3(2), pp. 59–68. Xu, L. et al. (2015) ‘The Study on Biological and Pharmacological Activity of Coumarins’, Proceedings of the 2015 Asia-Pacific Energy Equipment Engineering Research Conference, 9(Ap3er), pp. 135–138. doi: 10.2991/ap3er-15.2015.33. Zandi, K. et al. (2011) ‘Antiviral activity of four types of bioflavonoid against dengue virus type-2’, Virology Journal, 8, pp. 1–11. doi: 10.1186/1743-422X-8-560. Zhao, Y. L. et al. (2019) ‘Anti-inflammatory Effect of Pomelo Peel and Its Bioactive Coumarins’, Journal of Agricultural and Food Chemistry, 67(32), pp. 8810–8818. doi: 10.1021/acs.jafc.9b02511. Zielińska, D., Szawara-Nowak, D. and Zieliński, H. (2010) ‘Determination of the antioxidant activity of rutin and its contribution to the antioxidant capacity of diversifed buckwheat origin material by updated analytical strategies’, Polish Journal of Food and Nutrition Sciences, 60(4), pp. 315–321.




DOI: https://doi.org/10.18860/jim.v7i2.15444

Refbacks

  • There are currently no refbacks.


 

Editorial Office:

Faculty of Medical and Health Sciences,
Universitas Islam Negeri Maulana Malik Ibrahim
Gedung Ibnu Thufail Lt.1, Jln. Locari, Desa Tlekung, Kota Batu
Phone (+62) 85746163772, (+62) 8563588384, Faximile (+62) 341 558933
e-mail: medicaljournal@uin-malang.ac.id

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.