Interaksi Obat Antihipertensi Pada Pasien Hipertensi Rawat Jalan Di Puskesmas Banyumas Kabupaten Pringsewu
Abstract
Background: The prevalence of people suffering from hypertension is increasing globally, it is estimated that by 2025 many people will die from hypertension .in some cases of hypertension accompanied by comorbidities, in one prescription several drugs can be taken simultaneously and can cause drug related problems that can affect the patient's therapeutic results. Objectif : This study was to determine the potential interactions of antihypertensive drugs in hypertensive patients at the Banyumas Pringsewu Public Health Center. Methods : The research used is an observational research with a cross sectional research design and data collection is done prospectively. The sample used was medical records of outpatient hypertension patients at the Banyumas Pringsewu Health Center in March-April 2022 as many as 76 patients. Sampling method using non-probability sampling technique. The data was processed using the Medscape, Drug.com application and then classified based on the severity of the interactions that occurred. Results: The results obtained are drugs The most widely used antihypertensive is the ACE-inhibitor captoprilas much as 99% and the Calcium Antagonist group, namely amlodipine as much as 1%. As for There were 69 patients or 99% of patients with the potential for interaction, of which 6%represents minor severity, 90% is moderate severity, and 4% is grade major severity. Conclusion: The potential for drug interactions that occur at the Banyumas Public Health Center, Pringsewu Regency, is higher or more patients experience drug interactions, namely 91%.
Keyword : Hypertension, drug interactions, outpatient
Full Text:
PDFReferences
Dr. Cut Putri Arianie,M.H.K (2019). Hipertensi Penyakit Paling Banyak Diidap Masyarakat. Kementrian Kesehatan RI, 20-23.
Sudarsono,E.K.R., Sasmita,J.F.A., Handyasto,A.B., Kuswatiningsih,N.,& Arissaputra,S.S. (2017). Peningkatan Pengetahuan Terkait Hipertensi Guna Perbaikan Tekanan Darah pada Pemuda di Dusun Japanan, Margodadi, Seyegan, Sleman, Yogyakarta. Jurnal Pengabdian Masyarakat (Indonesia Journal of Community Engagement), 3(1), 26.
Junaedi, E., Yulianti, S., (2013). Hipertensi Kandas Berkat Herbal (1ed). Jakarta: FMedia (imprint Agro Media Pustaka).
Badan Prengawas Obat dan Makanan RI. (2015). Lampiran 1: Interaksi Obat. Basic Pharmacology & Drug Notes Edisi 2019. Makasar: MMn Publishing. 2019.
NP, B. H., & Dandan, K. L. (2019). Identifikasi Potensi Interaksi Antar Obat Pada Resep Umum Di Apotek Kimia Farma 58 Kota Bandung Bulan April 2019. Farmaka, 4 Nomor 2(April), 8.
Hendera, & Rahayu, S. (2018). Interaksi Antar Obat Pada Peresepan Pasien Rawat Inap Pediatrik Rumah Sakit X Dengan Menggunakan Aplikasi Medscape. Journal of Current Pharmaceutical Sciences, 1(2), 75–80.
Irmawartini, & Nuehaedah. (2017). Metodologi Penelitian. Jakarta: Kementrian Kesehatan RI.
Sochis, Soedarsono, & Ni'am, M.F. (2017). 84. Intergrated Implementation Conservation In DASS Serang (Study Case Institutional Group Of Land and Water Conservation Sampetan Village Subdistrict Ampel, District Boyolali). Procceding of International conference : Problem, Solution and Development of Coastal and Delta Areas Semarang, Indonesia. No.C-47,532.
Nuraeni, E. (2019). Usia Jenis Kelamin Berisiko Dengan Kejadian Hipertensi Di Klinik X Kota Tanggerang. 4(1), 1–6.
Winda, A., & Rahmatilah, D. L. (2019). Evaluasi Tingkat Kepatuhan Penggunaan Antihipertensi Pada Pasien Hipertensi Menggunakan Kuesioner MMAS-8 Di Penang Malaysia. Farmasi, 4(3), 23–33.
Tumundo, D. G., Wiyono, W. I., & Jayanti, M. (2021). Adherence Level Of Antihypertensive Drug Used In Hypertension Patients At Kema Health Center, North Minahasa Regency Tingkat Kepatuhan Penggunaan Obat Antihipertensi Pada Pasien bagi peningkatan kepatuhan pasien hipertensi dalam menggunakan obat antihipertensi. 10 (November), 1121–1128.
Istianah, I., Septiani, S., & Dewi, G. K. (2020). Mengidentifikasi Faktor Gizi pada Pasien Diabetes Mellitus Tipe 2 di Kota Depok Tahun 2019. Jurnal Kesehatan Indonesia (The Indonesian Journal of Health), X(2), 72–78.
Adikusuma, W., Qiyaam, N., & Yuliana, F. (2015). Kepatuhan Penggunaan Obat Antihipertensi di Puskesmas Pagesangan Mataram.Pharmascience, 2(2), 56–62.
Luthfi, M., Aziz, S., & Kusumastuti, E. (2014). Rasionalitas Penggunaan ACE Inhibitor pada Penderita Hipertensi di Bagian Penyakit Dalam RSUD Kayuagung dan RSMH Palembang.. 4(2), 67–76.
Cookson, M. D., & Stirk, P. M. R. (2019). Potensi Interaksi Obat Resep Pasien Hipertensi di Salah Satu Rumah Sakit Pemerintah di Kota Samarinda. 1(4), 208–213.
Agustin, O. A., & Fitrianingsih. (2020). Kajian interaksi obat berdasarkan kategori signifikansi klinis terhadap pola peresepan pasien Rawat Jalan Di Apotek X Jambi. Electronic Journal Scientific of Envitonmental Health and Diseases (e-SEHAD), 1(1), 1–10.
Tatro, D.S.,2001, Drug Interaction Fact, A wolterss Kluwer Company, St Louis Missouri.
Syafrin, M., & Hikmah, N. (2018). Studi Interaksi Obat Dan Manifestasi Klinik Pada Peresepan Di Puskesmas Bontolempangan Ii Kabupaten Gowa. Jurnal Farmasi Sandi Karsa, 4(7), 11–15. https://doi.org/10.36060/jfs.v4i7.20
Indriani, L., & Oktaviani, E. (2020). Kajian Interaksi Obat Antihipertensi Pada Pasien Rawat Inap di Salah Satu Rumah Sakit di Bogor, Indonesia. Majalah Farmasetika., 4 (Suppl 1), 212–219. https://doi.org/10.24198/mfarmasetika.v4i0.25884
Nurlaelah, I., Mukaddas, A., & Faustine, I. (2015). Kajian Interaksi Obat Pada Pengobatan Diabetes Melitus (Dm) Dengan Hipertensi Di Instalasi Rawat Jalan RSUD Undata Periode Maret-Juni Tahun 2014. Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal), 1(1), 35–41. https://doi.org/10.22487/j24428744.2015.v1.i1.4833
Nindya Mayaningtyas Dewi. (2021). Perbandingan Efektivitas Natrium Diklofenak Dan Deksametason Dalam Mengurangi Pembengkakan Pasca Odontektomi: Literature Review.
Medscape. 2018. Drug Interaction Checker [online] https://reference.medscape.com/drug-interactionchecker.Diakses tanggal 5 Juli 2018
Medscape.2022.captopril [online].https://reference.medscape.com/drug/capoten. captopril-captopril. Diakses tanggal 19 mei 2022
DOI: https://doi.org/10.18860/jim.v6i2.17454
Refbacks
- There are currently no refbacks.
Editorial Office:
Faculty of Medical and Health Sciences,
Universitas Islam Negeri Maulana Malik Ibrahim
Gedung Ibnu Thufail Lt.1, Jln. Locari, Desa Tlekung, Kota Batu
Phone (+62) 85746163772, (+62) 85259506000, Faximile (+62) 341 558933
e-mail: medicaljournal@uin-malang.ac.id
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.