Injeksi Vaksin Bacillus Calmette-Guérin (BCG) Sebagai Agen Imunoterapi Pada Kasus Kondiloma Akuminata

Lita Setyowatie, Rasinta Ayudya Deltania

Abstract


Abstrak

Latar Belakang: Kondiloma akuminata adalah infeksi menular seksual yang disebabkan Human Papillomavirus (HPV). Bacille-Calmette-Guerin (BCG) adalah vaksin hidup yang dilemahkan dan termasuk salah satu agen imunoterapi yang dapat menjadi alternatif terapi kondiloma akuminata.. Laporan Kasus: Perempuan berusia 23 tahun dengan keluhan muncul kutil sewarna kulit sejak 1 bulan tanpa disertai gatal dan nyeri. Pemeriksaan venereologi tampak papul sewarna kulit, multipel, batas tegas, bentuk dan ukuran bervariasi Acetowhite (+).Pasien didiagnosis kondiloma akuminata dan diberikan terapi vaksin BCG injeksi intralesi 0,5 ml dosis tunggal. Kesimpulan : Vaksin BCG meningkatkan aktivitas berbagai sel imun yang dapat merangsang penyembuhan kutil kelamin. Terapi injeksi intralesi  tunggal 0,5 ml menunjukkan penurunan lesi pasca 1 bulan injeksi. Injeksi vaksin BCG intralesi dapat menjadi pilihan terapi untuk kondiloma akuminata dengan keuntungan seperti keamanan, harga lebih murah, dan mudah didapatkan


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References


  1. Cameli, N., Mariano, M., Latini, A., Morrone, A. & Cristaudo, A., 2020. LASER safety measures for the treatment of genital warts in HIV+ patients during the COVID-19 pandemic. Dermatol. Ther., 33, e13750. [online] Available at: https://doi.org/10.1111/ddg.14060.
  2. Adebajo, S.B., Nowak, R.G., Adebiyi, R., Shoyemi, E., Ekeh, C., Ramadhani, H.O. et al., 2022. Prevalence and factors associated with anogenital warts among sexual and gender minorities attending a trusted community health center in Lagos, Nigeria. PLOS Glob Public Health, 2(11), e0001215. [online] Available at: https://doi.org/10.1371/journal.pgph.0001215.
  3. Diţescu, D., Istrate-Ofiţeru, A.M., Roşu, G.C., Iovan, L., Liliac, I.M., Zorilă, G.L., Bălăşoiu, M., Cercelaru, L., 2021. Clinical and pathological aspects of condyloma acuminatum - review of literature and case presentation. Rom J Morphol Embryol., 62(2), 369-383. [online] Available at: https://doi.org/10.47162/RJME.62.2.03.
  4. Salecha, A.J., Samanthula, H., Bommineni, M.R., Mandava, B. & Shaik, F.A., 2023. Intralesional Bacille Calmette Guerin as a therapeutic modality in the treatment of warts. Journal of Pakistan Association of Dermatologists, 33(2), pp. 400-407.
  5. Artosi, F., Cosio, T., Ansaldo, L., Cavasio, A., Sarmati, L., Bianchi, L., Campione, E., 2025. Treatment of Condyloma Acuminata with Tirbanibulin 1% Ointment in People Living with HIV: A Case Series with Literature Review. Infect. Dis. Rep., 17, 40. [online] Available at: https://doi.org/10.3390/idr17030040
  6. Immunotherapy Agents Use For Treatment of Warts, 2023. Journal of Pharmaceutical Negative Results, pp. 399–405. [online] Available at: https://doi.org/10.47750/pnr.2023.14.03.50.
  7. Pérez-Jacoiste Asín, M.A., Fernández-Ruiz, M., López-Medrano, F., Lumbreras, C., Tejido, A., San Juan, R., Arrebola-Pajares, A., Lizasoain, M., Prieto, S., Aguado, J.M., 2014. Bacillus Calmette-Guérin (BCG) infection following intravesical BCG administration as adjunctive therapy for bladder cancer: incidence, risk factors, and outcome in a single-institution series and review of the literature. Medicine (Baltimore), 93(17), 236-254.
  8. Gupta, S.K., 2016. Single dose intralesional immunotherapy with BCG of medically resistant condyloma acuminata of the penis: report of two cases. Int J Dermatol., 55(5), 583-586. [online] Available at: https://doi.org/10.1111/ijd.12900.
  9. Pati Aji Achdiat, Oki Suwarsa, Yudi Mulyana Hidayat, Mohamad Nasir Shafiee, Reiva Farah Dwiyana, Hendra Gunawan, Rasmia Rowawi & Reyshiani Johan, 2023. Successful treatment of anogenital warts with single dose Bacillus Calmette Guerin vaccine without prior sensitization in tuberculosis endemic country: Two case report. Human Vaccines & Immunotherapeutics, 19(1), 2187591. [online] Available at: https://doi.org/10.1080/21645515.2023.2187591.
  10. Jaisinghani, S., et al., 2019. Bacillus Calmette–Guerin Immunotherapy for Recurrent Multiple Warts: An Open-Label Uncontrolled Study. Indian J Dermatol., 64, 164.
  11. Liu, X. & Qi, M., 2023. The effectiveness of different immunotherapies in the treatment of condyloma acuminatum: a network meta analysis of randomized clinical trials. Front. Med., 10, 1260139. [online] Available at: https://doi.org/10.3389/fmed.2023.1260139.
  12. Salman, S., Ahmed, M.S., Ibrahim, A.M., Mattar, O.M., El-Shirbiny, H., Sarsik, S., 2019. Intralesional immunotherapy for the treatment of warts: a network meta analysis. J Am Acad Dermatol., 80, 922–930.e4. [online] Available at: https://doi.org/10.1016/j.jaad.2018.07.003.
  13. Kim, J.K., Park, Y.G., Kim, B.G., 2022. Correlation between recurrence of anorectal condyloma acuminatum and human papilloma virus subtype. Genes Genom., 44, 389-394.
  14. Sugiyanto, R.W., Kristiyani, E. & Kwartantaya, K., 2025. Navigating Diagnosis and Treatment of Perianal Condyloma Acuminata in a Bisexual Man: Clinical and Histopathological Insights. Bioscientia Medicina: Journal of Biomedicine and Translational Research, 9(7), 8006-8018. [online] Available at: https://doi.org/10.37275/bsm.v9i7.1332.
  15. Walensky RP, Jernigan DB, Bunnell R, et al. Morbidity and Mortality Weekly Report Sexually Transmitted Infections Treatment Guidelines, 2021 Centers for Disease Control and Prevention MMWR Editorial and Production Staff (Serials) MMWR Editorial Board. 2021.




DOI: https://doi.org/10.18860/jim.v9i2.35175

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