Potensi Fenol pada Phyllanthus niruri L. sebagai Immunomodulator Tuberkulosis

Nurin Nadzifatil Fitriyah

Abstract


Background:   One of the goals set in the Sustainable Development Goals (SDGs) is to ensure healthy lives and promote well-being for all people at all ages, one of which is through the control of Tuberculosis (TB). Indonesia is the country with the second highest TB rate in the world. Standard treatment using a combination of anti-TB drugs (RHZE) is effective, but carries the risk of hepatotoxic side effects. Indonesia has great potential in the development of phytopharmaceuticals, one of which is Phyllanthus niruri, which contains bioactive compounds such as lignans, tannins, polyphenols, alkaloids, terpenoids, and flavonoids. These compounds can improve the immune system and have the potential to be used as adjuvants in OAT therapy to strengthen the effectiveness of TB treatment and reduce side effects. .  Objectif  Examining the use of Phyllanthus niruri and its contents and benefits as an immunomodulator for Tuberculosis (TB). Methods  This study uses a literature review with sources from Science Direct, Google Scholar, Pubmed NCBI, and Taylor & Francis Online, using the keywords "Phyllanthus niruri" AND "tuberculosis" AND "immunomodulator" obtained 139 articles. Furthermore, re-filtering was carried out based on the content so that 16 articles were obtained.  Results The results of the study showed that the phytochemical content, especially phenol, can induce the proliferation of peripheral blood mononuclear cells, increase the release of Nitric Oxide, and increase the phagocytic activity of macrophages, while other contents, namely flavonoids and alkaloids, act as hepatoprotective. Conclusion :  Phyllanthus niruri is effective as an adjuvant for OAT therapy to increase immunity and accelerate TB healing.


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References


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DOI: https://doi.org/10.18860/jim.v9i1.32284

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