Transmission Dynamics of Dengue Disease Incorporating Treatment, Mass Awareness, and Wolbachia Intervention
Abstract
The basic reproduction number (R0) is derived using the Next Generation Matrix (NGM) method and serves as a threshold parameter for disease spread. Numerical simulations show
that when R0 < 1, the system converges to the disease-free equilibrium, indicating that the disease will eventually die out. Conversely, by adjusting the parameter δ such that R0 > 1,
the system becomes stable at the endemic equilibrium, implying the persistence of the disease within the population. These findings highlight the importance of controlling key parameters through integrated intervention strategies to reduce R0 below unity.
Keywords
Full Text:
PDFReferences
[1] H. Harapan, A. Michie, R. T. Sasmono, and A. Imrie. “Dengue: A minireview”. In: Viruses 12.8 (Aug. 2020), p. 829. doi: 10.3390/v12080829.
[2] World Health Organization. Dengue and severe dengue. Accessed: 2024. 2024. https : //www.who.int/news-room/fact-sheets/detail/dengue-and-severe-dengue.
[3] A. Sofyan Anas et al. “Faktor Risiko Penyakit Demam Berdarah Dengue (Risk Factors for Dengue Fever): Artikel Review”. In: Jurnal Kolaboratif Sains 8.6 (2025), pp. 3169–3176. doi: 10.56338/jks.v8i6.7913.
[4] M. Sobari, I. G. N. M. Jaya, and B. N. Ruchjana. “Spatial Analysis of Dengue Disease in Jakarta Province”. In: CAUCHY: Jurnal Matematika Murni dan Aplikasi 7.4 (May 2023), pp. 535–547. doi: 10.18860/ca.v7i4.17423.
[5] R. Hutapea and I. Husein. “Model Koefisien Bervariasi Spasial Bayesian untuk Memperkirakan Risiko Relatif Penyakit Demam Berdarah Dengue di Kota Medan”. In: Jurnal Matematika Juli 5 (2025). https://ejurnal.unisap.ac.id/leibniz/index.
[6] Kementerian Kesehatan RI. Profil Kesehatan Indonesia 2024. Kementerian Kesehatan Republik Indonesia. 2024. https://kemkes.go.id/id/profil-kesehatan-indonesia-2024.
[7] A. A. Hershan. “Dengue Virus: Molecular Biology and Recent Developments in Control Strategies, Prevention, Management, and Therapeutics”. In: Journal of Pharmacy and Bioallied Sciences (June 2023). doi: 10.1177/0976500X231204401.
[8] M. Palanichamy Kala, A. L. St. John, and A. P. S. Rathore. “Dengue: Update on Clinically Relevant Therapeutic Strategies and Vaccines”. In: Current Treatment Options in Infectious Diseases 15.2 (Apr. 2023), pp. 27–52. doi: 10.1007/s40506-023-00263-w.
[9] M. Narendran, S. Chate, and R. Patil. “Community-based intervention to dengue prevention: Insights from urban residents in Pune, using the health belief model”. In: Clinical Epidemiology and Global Health 30 (Nov. 2024). doi: 10.1016/j.cegh.2024.101779.
[10] C. A. Djuma, N. Achmad, A. R. Nuha, I. K. Hasan, and A. Arsal. “Model Matematika Penyebaran Penyakit Demam Berdarah Dengue dengan Faktor Kesadaran Sosial: Analisis dan Simulasi”. In: Jambura Journal of Mathematics 7.2 (Aug. 2025). doi: 10.37905/jjom.v7i2.33921.
[11] B. Z. Naaly, T. Marijani, A. Isdory, and J. Z. Ndendya. “Mathematical modeling of the effects of vector control, treatment and mass awareness on the transmission dynamics of dengue fever”. In: Computer Methods and Programs in Biomedicine Update 6 (Jan. 2024). doi: 10.1016/j.cmpbup.2024.100159.
[12] W. H. Cahyati, N. Siyam, and E. Nugroho. “Distribution of Voltage-gated Sodium Channel Mutations in Aedes Aegypti Populations from Rural Areas of Indonesia”. In: The Open Public Health Journal 16.1 (Jan. 2024). doi: 10.2174/0118749445255879231003110635.
[13] A. Ahamed, S. Ali, and M. Hoque. “Wolbachia-Based biocontrol of Aedes aegypti: Current Progress, Challenges, and future prospects”. In: Journal of Invertebrate Pathology (Feb. 2025), p. 108468. doi: 10.1016/j.jip.2025.108468.
[14] K. L. Anders et al. “Reduced dengue incidence following deployments of Wolbachia-infected Aedes aegypti in Yogyakarta, Indonesia: A quasi-experimental trial using controlled interrupted time series analysis”. In: Gates Open Research 4 (2020). doi: 10 . 12688 / gatesopenres.13122.1.
[15] A. Utarini, C. Indriani, R. A. Ahmad, et al. “Efficacy of Wolbachia-Infected Mosquito Deployments for the Control of Dengue”. In: New England Journal of Medicine 384.23 (June 2021), pp. 2177–2186. doi: 10.1056/nejmoa2030243.
[16] A. Sa’adah and D. K. Sari. “Mathematical Models of Dengue Transmission Dynamics with Vaccination and Wolbachia Parameters and Seasonal Aspects”. In: Barekeng: Jurnal Ilmu Matematika dan Terapan 17.4 (Dec. 2023), pp. 2305–2316. doi: 10.30598/barekengvol17iss4pp2305-2316.
[17] M. Z. Ndii, N. Anggriani, B. S. Djahi, S. T. Tresna, and F. Inayaturohmat. “Numerical simulations of a two-strain dengue model to investigate the efficacy of the deployment of Wolbachia-carrying mosquitoes and vaccination for reducing the incidence of dengue infections”. In: Journal of Biosafety and Biosecurity 6.4 (Dec. 2024), pp. 244–251. doi: 10.1016/j.jobb.2024.08.003.
[18] H. Zhang and R. Lui. “Releasing Wolbachia-infected Aedes aegypti to prevent the spread of dengue virus: A mathematical study”. In: Infectious Disease Modelling 5 (Jan. 2020), pp. 142–160. doi: 10.1016/j.idm.2019.12.004.
[19] S. Safaei, M. Derakhshan-sefidi, and A. Karimi. “Wolbachia: A bacterial weapon against dengue fever- a narrative review of risk factors for dengue fever outbreaks”. In: New Microbes and New Infections (June 2025). doi: 10.1016/j.nmni.2025.101578.
[20] A. Minwuyelet et al. “Symbiotic Wolbachia in mosquitoes and its role in reducing the transmission of mosquito-borne diseases: updates and prospects”. In: Frontiers in Microbiology (Oct. 2023). doi: 10.3389/fmicb.2023.1267832.
[21] Abu Hanifah Al Faruqy and Budi Priyo Prawoto. “Bilangan Reproduksi Dasar Model Penyebaran Penyakit Demam Berdarah Dengue dengan Adanya Penyebaran Bakteri Wolbachia”. In: MATHunesa: Jurnal Ilmiah Matematika 12.02 (2024), pp. 284–291. https://doi.org/10.26740/mathunesa.v12n2.p284-291.
[22] World Health Organization. Dengue: Guidelines for Diagnosis, Treatment, Prevention and Control. World Health Organization. Geneva, 2009. https://www.who.int/tdr.
[23] A. Khanam, H. Gutiérrez-Barbosa, K. E. Lyke, and J. V. Chua. “Immune-Mediated Pathogenesis in Dengue Virus Infection”. In: Viruses (Nov. 2022). doi: 10.3390/v14112575.
[24] F. D. Frentiu et al. “Limited Dengue Virus Replication in Field-Collected Aedes aegypti Mosquitoes Infected with Wolbachia”. In: PLoS Neglected Tropical Diseases 8.2 (2014). doi: 10.1371/journal.pntd.0002688.
[25] W. Tantowijoyo et al. “Stable establishment of wMel Wolbachia in Aedes aegypti populations in Yogyakarta, Indonesia”. In: PLoS Neglected Tropical Diseases 14.4 (Apr. 2020), pp. 1–13. doi: 10.1371/journal.pntd.0008157.
[26] N. Nurkhanifah, A. Suryanto, and I. Darti. “Dynamics of Lumpy Skin Disease Model with Vaccination and Environmental Transmission”. In: CAUCHY: Jurnal Matematika Murni dan Aplikasi 10.1 (2025), pp. 133–146. doi: 10.18860/ca.v10i1.29969.
[27] D. Medhi, G. Sarma, and A. Shyam. “Stability Analysis of Linear Systems Using the Routh-Hurwitz Criterion: Theory and Applications”. In: Journal of Computational Analysis and Aplication 33.8 (2024), pp. 903–907. https://www.eudoxuspress.com/index.php/pub/article/view/1496.
[28] R. Resmawan and L. Yahya. “Sensitivity Analysis of Mathematical Model of Coronavirus Disease (COVID-19) Transmission”. In: CAUCHY: Jurnal Matematika Murni dan Aplikasi 6.2 (May 2020), pp. 91–99. doi: 10.18860/ca.v6i2.9165.
DOI: https://doi.org/10.18860/cauchy.v11i1.39026
Refbacks
- There are currently no refbacks.
Copyright (c) 2026 Rafika Nanda Agustina, Budi Priyo Prawoto

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Editorial Office
Mathematics Department,
Universitas Islam Negeri Maulana Malik Ibrahim Malang
Gajayana Street 50 Malang, East Java, Indonesia 65144
Faximile (+62) 341 558933
e-mail: cauchy@uin-malang.ac.id

CAUCHY: Jurnal Matematika Murni dan Aplikasi is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.







